IIT Hyderabad
Coureses Offered:
Course Type: Elective Credit: 2
Description: The aim of this course is to provide insight of 3D bioprinting and allied technologies in biomedical and pharmaceutical applications. It will provide the basics and mechanisms of 3D bioprinting, 3D design software, and 3D tissue/organ printing. In addition, it will also provide nitty gritty of various biofabrication processes, such as the selection and development of biomaterial formulation (bioinks), modulating properties of biomaterials, and controlling different processing conditions. Finally, it will provide state-of-the-art examples of translation of biofabricated products from bench towards the bedside.
In this elective course, students will be introduced to all topics within biofabrication and bioprinting to provide them with a broad basic knowledge on the theoretical background, current status and future perspectives of the field. Besides the theoretical parts, students will work in teams on literature presentations. They will also prepare, present and defend a short scientific presentation.
This course will cover the basics of various 3D bioprinting techniques used in biofabrication; processing of medical imaging data into printable CAD models, and fabricating models on a 3D bioprinter; development of suitable bioinks; critical parameters of bioink for biofabrication; various process parameters and their role in biofabrication; Various 3D bioprinted in vitro, in vivo and ex vivo research models and techniques; in vitro manipulation of cells and biomaterials with a bioprinter to engineer tissues for regenerative medicine or in vitro models; biofabrication-based strategy from bench-to-bed to address a specific clinical problem; ethical issue related to biofabrication.
Syllabus:
References:
Books:
1. Atala et al., Essentials of 3D Biofabrication and Translation. 1st edition, ISBN-13: 978-0128009727.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
3. Forgacs et al., Biofabrication - Micro- and Nano-fabrication, Printing, Patterning and Assemblies, 1st Edition, ISBN 9781455728527
Articles:
1. Derby B. Printing and prototyping of tissues and scaffolds. Science. 2012. 338:921-6.
2. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012. 336:1124-8.
3. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nature Biotechnology. 2014. 32:773-85.
4. Pati F, Gantelius J, Svahn HA. 3D Bioprinting of Tissue/Organ Models. Angewandte Chemie International Edition. 2016.55:4650-65.
Description: The aim of this course is to provide insight of 3D bioprinting and allied technologies in biomedical and pharmaceutical applications. It will provide the basics and mechanisms of 3D bioprinting, 3D design software, and 3D tissue/organ printing. In addition, it will also provide nitty gritty of various biofabrication processes, such as the selection and development of biomaterial formulation (bioinks), modulating properties of biomaterials, and controlling different processing conditions. Finally, it will provide state-of-the-art examples of translation of biofabricated products from bench towards the bedside.
In this elective course, students will be introduced to all topics within biofabrication and bioprinting to provide them with a broad basic knowledge on the theoretical background, current status and future perspectives of the field. Besides the theoretical parts, students will work in teams on literature presentations. They will also prepare, present and defend a short scientific presentation.
This course will cover the basics of various 3D bioprinting techniques used in biofabrication; processing of medical imaging data into printable CAD models, and fabricating models on a 3D bioprinter; development of suitable bioinks; critical parameters of bioink for biofabrication; various process parameters and their role in biofabrication; Various 3D bioprinted in vitro, in vivo and ex vivo research models and techniques; in vitro manipulation of cells and biomaterials with a bioprinter to engineer tissues for regenerative medicine or in vitro models; biofabrication-based strategy from bench-to-bed to address a specific clinical problem; ethical issue related to biofabrication.
Syllabus:
References:
Books:
1. Atala et al., Essentials of 3D Biofabrication and Translation. 1st edition, ISBN-13: 978-0128009727.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
3. Forgacs et al., Biofabrication - Micro- and Nano-fabrication, Printing, Patterning and Assemblies, 1st Edition, ISBN 9781455728527
Articles:
1. Derby B. Printing and prototyping of tissues and scaffolds. Science. 2012. 338:921-6.
2. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012. 336:1124-8.
3. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nature Biotechnology. 2014. 32:773-85.
4. Pati F, Gantelius J, Svahn HA. 3D Bioprinting of Tissue/Organ Models. Angewandte Chemie International Edition. 2016.55:4650-65.
Course Type: Core Credit: 2
Description: This course is intended to understand the origin of signals in biosystems and living organisms, their sensing, detection and meaningful processing for practical diagnostic sensing applications. Various engineering aspects of the detection, acquisition, processing, and display of signals, biomedical sensors for measurements of biopotentials, ECG, force, displacement, blood pressure and temperature sensors, will be addressed in this course. The course includes work involving circuits, electronics, sensor design and interfaces for building complete biomedical instrumentation.
Syllabus: Displacement sensors: Resistive sensors, strain sensors, bridge circuits, Inductive, capacitive, piezo-electric sensors; Temperature sensors: thermoelectric, radiation thermometry, thermistors, fiber-optic sensors; Biopotentials: Origin of biopotentials, Cell, nerve and muscle protentials, Action potential, resting potential, Membrane structure and Nernst Equation, Nerve cell, Biopotential electrodes and biopotential amplifiers, ECG principle, sensing, 12-Lead ECG PQRS characteristics.
References:
1. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
2. Operational Amplifiers and linear ICs,R. A. Gayakwad, Phi Learning, 2009.3. Additional research papers distributed in class.
Description: This course is intended to understand the origin of signals in biosystems and living organisms, their sensing, detection and meaningful processing for practical diagnostic sensing applications. Various engineering aspects of the detection, acquisition, processing, and display of signals, biomedical sensors for measurements of biopotentials, ECG, force, displacement, blood pressure and temperature sensors, will be addressed in this course. The course includes work involving circuits, electronics, sensor design and interfaces for building complete biomedical instrumentation.
Syllabus: Displacement sensors: Resistive sensors, strain sensors, bridge circuits, Inductive, capacitive, piezo-electric sensors; Temperature sensors: thermoelectric, radiation thermometry, thermistors, fiber-optic sensors; Biopotentials: Origin of biopotentials, Cell, nerve and muscle protentials, Action potential, resting potential, Membrane structure and Nernst Equation, Nerve cell, Biopotential electrodes and biopotential amplifiers, ECG principle, sensing, 12-Lead ECG PQRS characteristics.
References:
1. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
2. Operational Amplifiers and linear ICs,R. A. Gayakwad, Phi Learning, 2009.3. Additional research papers distributed in class.
Course Type: Elective Credit: 2
Description: This course will cover the various biomedical devices and diagnostics in health care.
Syllabus: Electrochemical devices for biosensing: blood glucose monitoring: Principle and working, cholesterol sensing, microfluidic devices, and Lab on a chip. (lectures + Lab); Blood pressure monitoring, Audiometry, Optical Pulse oximetry. ( lectures+ Lab); Electromyography principle, ECG and holter monitor devices, Arrythmia and Defibrillation and telemetry systems for health care ( lectures + Lab); Therapeutic instrumentation such as pacemakers, defibrillators and prosthetic devices will be reviewed.
References:
1. Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2. Fundementals of Photonics B. E A. Saleh and M. C. Teich John Wiley 2009.
3. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
4. Additional materials distributed in class.
Description: This course will cover the various biomedical devices and diagnostics in health care.
Syllabus: Electrochemical devices for biosensing: blood glucose monitoring: Principle and working, cholesterol sensing, microfluidic devices, and Lab on a chip. (lectures + Lab); Blood pressure monitoring, Audiometry, Optical Pulse oximetry. ( lectures+ Lab); Electromyography principle, ECG and holter monitor devices, Arrythmia and Defibrillation and telemetry systems for health care ( lectures + Lab); Therapeutic instrumentation such as pacemakers, defibrillators and prosthetic devices will be reviewed.
References:
1. Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2. Fundementals of Photonics B. E A. Saleh and M. C. Teich John Wiley 2009.
3. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
4. Additional materials distributed in class.
Course Type: Elective Credit: 1
Description: The course intends to introduce the students of first year interdisciplinary masters programs to scientific computing and tools for the same. This course will be compulsory for students with basic degree in Life sciences and others not exposed to quantitative sciences. The main contents of the course are : Matrices, matrix operations, factorisations, eigen values, transforms, Linear equations; Coding in MATLAB and Python using matrices as elementary structures; Probability and random variables;statistical hypothesis testing.
Syllabus:
References:
1. Strang, Gilbert. Introduction to Linear Algebra, Wellesley Cambridge Press.
Description: The course intends to introduce the students of first year interdisciplinary masters programs to scientific computing and tools for the same. This course will be compulsory for students with basic degree in Life sciences and others not exposed to quantitative sciences. The main contents of the course are : Matrices, matrix operations, factorisations, eigen values, transforms, Linear equations; Coding in MATLAB and Python using matrices as elementary structures; Probability and random variables;statistical hypothesis testing.
Syllabus:
References:
1. Strang, Gilbert. Introduction to Linear Algebra, Wellesley Cambridge Press.
Course Type: Core Credit: 1
Description:
Syllabus: Introduction to concept of stress/strain and elasticity - Normal and Shear stress - Linear models - Isotropic and Anisotropic materials - Matrix formulation to solve problems of elasticity - Biomechanics of body joints (knee and ankle) - Soft tissue mechanics and Introduction to non - linear models.
References:
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.
Description:
Syllabus: Introduction to concept of stress/strain and elasticity - Normal and Shear stress - Linear models - Isotropic and Anisotropic materials - Matrix formulation to solve problems of elasticity - Biomechanics of body joints (knee and ankle) - Soft tissue mechanics and Introduction to non - linear models.
References:
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.
Course Type: Elective Credit: 1
Description: This course is an undergraduate's introduction to the fascinating world of the brain and its study. The course will give an overview of the structure and function of the brain along with the nervous system using interesting case studies and descriptions of experiments. Students will be introduced to various disciplines that go under the umbrella term of neurosciences like Cognitive, behavioral, network, cellular, developmental or computational neurosciences. The course will emphasize on the interdisciplinary nature of modern neuroscience and opportunities for people from various backgrounds to contribute to it. Towards the end of the course students pick a landmark paper or case study and present the same in class.
Syllabus: Introduction - Organization of the brain and its function; Behaviour and cognition; Systems : Motor, sensory and learning; Regions; Networks; Neuron; Ion channels; Neural development and disease; Role of experiments and computation in neuroscience; Methods in neuroscience; The interdisciplinary nature of neuroscience
References:
1. Neuroscience, Purves et al, Sinauer Associates Inc, (2010).
Description: This course is an undergraduate's introduction to the fascinating world of the brain and its study. The course will give an overview of the structure and function of the brain along with the nervous system using interesting case studies and descriptions of experiments. Students will be introduced to various disciplines that go under the umbrella term of neurosciences like Cognitive, behavioral, network, cellular, developmental or computational neurosciences. The course will emphasize on the interdisciplinary nature of modern neuroscience and opportunities for people from various backgrounds to contribute to it. Towards the end of the course students pick a landmark paper or case study and present the same in class.
Syllabus: Introduction - Organization of the brain and its function; Behaviour and cognition; Systems : Motor, sensory and learning; Regions; Networks; Neuron; Ion channels; Neural development and disease; Role of experiments and computation in neuroscience; Methods in neuroscience; The interdisciplinary nature of neuroscience
References:
1. Neuroscience, Purves et al, Sinauer Associates Inc, (2010).
Course Type: Core Credit: 0.5
Description: This course is intended for basic understanding of cell physiology in the engineers’ perspective. The students need to understand the cellular structure and physiological functions.
Syllabus: Cell structure and its organelles; Cell membrane; Cell homeostasis; Nucleus structure and function of its different components.
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Description: This course is intended for basic understanding of cell physiology in the engineers’ perspective. The students need to understand the cellular structure and physiological functions.
Syllabus: Cell structure and its organelles; Cell membrane; Cell homeostasis; Nucleus structure and function of its different components.
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Course Type: Core Credit: 1.5
Description: This course is intended for basic understanding of human physiology in the engineers’ perspective. The students need to understand different physiological systems; and their dysfunction by applying engineering and mathematics knowledge. The important systems which may be covered are respiratory, renal, endocrine, gastro-intestinal tract, cutaneous, and other relvant systems.
Syllabus: Respiratory: anatomy, gas exchange, acid-base balance; Renal: anatomy, ion exchange, transport of metabolites; Gastro-intestinal tract: anatomy, absorption of micro-nutrients, dysfunction; Cutaneous system: anatomy, temperature regulation; Endocrine: basic function, major endocrine organs and their regulation, bone physiology
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Description: This course is intended for basic understanding of human physiology in the engineers’ perspective. The students need to understand different physiological systems; and their dysfunction by applying engineering and mathematics knowledge. The important systems which may be covered are respiratory, renal, endocrine, gastro-intestinal tract, cutaneous, and other relvant systems.
Syllabus: Respiratory: anatomy, gas exchange, acid-base balance; Renal: anatomy, ion exchange, transport of metabolites; Gastro-intestinal tract: anatomy, absorption of micro-nutrients, dysfunction; Cutaneous system: anatomy, temperature regulation; Endocrine: basic function, major endocrine organs and their regulation, bone physiology
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Course Type: Core Credit: 1
Description: This is an introductory course of biomaterials where materials are using for human health care. This course will provide a broad overview to the student about different types of materials and their application in human health care.
Syllabus: Introduction of different generations of biomaterials, Different class of materials used in medicine, Understanding the general properties of different classes of materials to be used as biomaterials, Familiarity with biological response to biomaterials, biocompatibility and hemocompatibility.
References:
1. An Introduction to Materials in Medicine, Edited by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. (Elsevier Academic Press, ISBN: 0-12-582463-7)
2. Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
Description: This is an introductory course of biomaterials where materials are using for human health care. This course will provide a broad overview to the student about different types of materials and their application in human health care.
Syllabus: Introduction of different generations of biomaterials, Different class of materials used in medicine, Understanding the general properties of different classes of materials to be used as biomaterials, Familiarity with biological response to biomaterials, biocompatibility and hemocompatibility.
References:
1. An Introduction to Materials in Medicine, Edited by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. (Elsevier Academic Press, ISBN: 0-12-582463-7)
2. Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
Course Type: Elective Credit: 2
Description: The aim of this laboratory course is to provide insight of methods and protocols of biofabrication and allied technologies. It will provide the basics and mechanisms of 3D bioprinting, 3D design software, and 3D tissue/organ printing. In addition, it will also provide hands on training of various biofabrication processes, such as the selection and development of biomaterial formulation (bioinks), modulating properties of biomaterials, controlling different processing conditions and biofabrication of 3D structures.
In this elective course, students will be introduced to all topics within biofabrication technology to provide them with a broad knowledge on the practical background, operation, and applications. Besides this, students will work in teams on experimental work. They will also prepare, present and defend a short scientific presentation.
Syllabus: Various 3D bioprinting techniques used in biofabrication; processing of medical imaging data into printable CAD models, and fabricating models on a 3D bioprinter; development of suitable bioinks; critical parameters of bioink for biofabrication; various process parameters and their role in biofabrication; Various 3D bioprinted in vitro, in vivo and ex vivo research models and techniques; in vitro manipulation of cells and biomaterials with a bioprinter to engineer tissues for regenerative medicine or in vitro models.
References:
Books:
1. Atala et al., Essentials of 3D Biofabrication and Translation. 1st edition, ISBN-13: 978-0128009727.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
3. Forgacs et al., Biofabrication - Micro- and Nano-fabrication, Printing, Patterning and Assemblies, 1st Edition, ISBN 9781455728527
Articles:
1. Derby B. Printing and prototyping of tissues and scaffolds. Science. 2012. 338:921-6.
2. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012. 336:1124-8.
3. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nature Biotechnology. 2014. 32:773-85.
4. Pati F, Gantelius J, Svahn HA. 3D Bioprinting of Tissue/Organ Models. Angewandte Chemie International Edition. 2016.55:4650-65.
Description: The aim of this laboratory course is to provide insight of methods and protocols of biofabrication and allied technologies. It will provide the basics and mechanisms of 3D bioprinting, 3D design software, and 3D tissue/organ printing. In addition, it will also provide hands on training of various biofabrication processes, such as the selection and development of biomaterial formulation (bioinks), modulating properties of biomaterials, controlling different processing conditions and biofabrication of 3D structures.
In this elective course, students will be introduced to all topics within biofabrication technology to provide them with a broad knowledge on the practical background, operation, and applications. Besides this, students will work in teams on experimental work. They will also prepare, present and defend a short scientific presentation.
Syllabus: Various 3D bioprinting techniques used in biofabrication; processing of medical imaging data into printable CAD models, and fabricating models on a 3D bioprinter; development of suitable bioinks; critical parameters of bioink for biofabrication; various process parameters and their role in biofabrication; Various 3D bioprinted in vitro, in vivo and ex vivo research models and techniques; in vitro manipulation of cells and biomaterials with a bioprinter to engineer tissues for regenerative medicine or in vitro models.
References:
Books:
1. Atala et al., Essentials of 3D Biofabrication and Translation. 1st edition, ISBN-13: 978-0128009727.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
3. Forgacs et al., Biofabrication - Micro- and Nano-fabrication, Printing, Patterning and Assemblies, 1st Edition, ISBN 9781455728527
Articles:
1. Derby B. Printing and prototyping of tissues and scaffolds. Science. 2012. 338:921-6.
2. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012. 336:1124-8.
3. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nature Biotechnology. 2014. 32:773-85.
4. Pati F, Gantelius J, Svahn HA. 3D Bioprinting of Tissue/Organ Models. Angewandte Chemie International Edition. 2016.55:4650-65.
Course Type: Elective Credit: 1
Description: The primary objective of this course is to build basic knowledge in materials science to understand the properties of different types of materials and their use as biomaterials. Gain knowledge on the advanced biomaterials in health care, Fundamental understanding of biological response to biomaterials. Knowledge of biomaterials requirement for certain medical applications. This course will help students to design a novel biomaterial for the specific application.
Syllabus:
References:
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461)Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Materials Science and Engineering: An Introduction - Callister (John Wiley and Sons; ISBN 0-471-13576-3).
Description: The primary objective of this course is to build basic knowledge in materials science to understand the properties of different types of materials and their use as biomaterials. Gain knowledge on the advanced biomaterials in health care, Fundamental understanding of biological response to biomaterials. Knowledge of biomaterials requirement for certain medical applications. This course will help students to design a novel biomaterial for the specific application.
Syllabus:
References:
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461)Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Materials Science and Engineering: An Introduction - Callister (John Wiley and Sons; ISBN 0-471-13576-3).
Course Type: Elective Credit: 1
Description:
Syllabus: Introduction to Micro Nano scale phenomena – Biochips and Microfluidic Technology – Analogy with electrical circuits – Simple modeling designs – Electrokinetic manipulation of cells and macromolecules (Proteins/DNA) – Introduction to Micro Nano fabrication - Applications of Immunoassay On Chip – Outline and overview of Single cell Nanobiology on Chip.
References:
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.
Description:
Syllabus: Introduction to Micro Nano scale phenomena – Biochips and Microfluidic Technology – Analogy with electrical circuits – Simple modeling designs – Electrokinetic manipulation of cells and macromolecules (Proteins/DNA) – Introduction to Micro Nano fabrication - Applications of Immunoassay On Chip – Outline and overview of Single cell Nanobiology on Chip.
References:
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.
Course Type: Elective Credit: 1
Description: This course is a laboratory based practical course for PhD and M.Tech students where student will prepare biomaterials for tissue engineering and drug delivery. In this course we will emphasize on the preparation of different type of scaffold and nanocarrier for tissue engineering and drug delivery application respectively. Students also learn the physical and biological characterization technique of these biomaterials. The biological characterization techniques include stem cells/cells base evaluation of these biomaterials.
Syllabus:
References:
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461) Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Relevent journal publications.
Description: This course is a laboratory based practical course for PhD and M.Tech students where student will prepare biomaterials for tissue engineering and drug delivery. In this course we will emphasize on the preparation of different type of scaffold and nanocarrier for tissue engineering and drug delivery application respectively. Students also learn the physical and biological characterization technique of these biomaterials. The biological characterization techniques include stem cells/cells base evaluation of these biomaterials.
Syllabus:
References:
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461) Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Relevent journal publications.
Course Type: Elective Credit: 2
Description: The proposed course is to introduce the origin of neurophysiological signals that can be obtained by invasive and non-invasive means. Signals such as spiking unit activity, local field potentials (LFP), electro-corticogram (ECoG), electroencephalogram (EEG) and magnetoencephalogram (MEG), near-infrared spectroscopy will be covered.
Syllabus:
• Signal processing basics– Fourier analysis, Hilbert transform, wavelet transform, multitapering
• Origin and biophysics of unit activity, LFP, ECoG, EEG and MEG signals
• Neurophysiological rhythms, spectral bands of physiological interest – theta, alpha, beta, gamma activity
• Acquisition, artefacts, artefact suppression, processing algorithms
• Evoked fields, time-frequency representation of neurophysiological signals, value of spectral analysis
• Motor evoked potentials - nerve stimulation
• Applications in clinical setting
o Unit activity, motor evoked fields, nerve stimulation in intra-operative neurophysiological monitoring
o Nerve conduction tests for diagnosis of neurological disorders
o ECoG and MEG/EEG for epilepsy diagnosis and surgical planning
References:
1. Michael X Cohen - Analyzing Neural Time Series Data: Theory and Practice (The MIT Press) 1st Edition. ISBN: 9780262019873
2. Niedermeyer & Lopez da Silva - Niedermeyer's Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (Lippincott Williams and Wilkins) 5th Edition. ISBN: 9780781789424
3. Malmivuo & Plonsey – Bioelectromagnetism- Principles and Applications of Bioelectric and Biomagnetic Fields (Oxford University Press) 1995<
Description: The proposed course is to introduce the origin of neurophysiological signals that can be obtained by invasive and non-invasive means. Signals such as spiking unit activity, local field potentials (LFP), electro-corticogram (ECoG), electroencephalogram (EEG) and magnetoencephalogram (MEG), near-infrared spectroscopy will be covered.
Syllabus:
• Signal processing basics– Fourier analysis, Hilbert transform, wavelet transform, multitapering
• Origin and biophysics of unit activity, LFP, ECoG, EEG and MEG signals
• Neurophysiological rhythms, spectral bands of physiological interest – theta, alpha, beta, gamma activity
• Acquisition, artefacts, artefact suppression, processing algorithms
• Evoked fields, time-frequency representation of neurophysiological signals, value of spectral analysis
• Motor evoked potentials - nerve stimulation
• Applications in clinical setting
o Unit activity, motor evoked fields, nerve stimulation in intra-operative neurophysiological monitoring
o Nerve conduction tests for diagnosis of neurological disorders
o ECoG and MEG/EEG for epilepsy diagnosis and surgical planning
References:
1. Michael X Cohen - Analyzing Neural Time Series Data: Theory and Practice (The MIT Press) 1st Edition. ISBN: 9780262019873
2. Niedermeyer & Lopez da Silva - Niedermeyer's Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (Lippincott Williams and Wilkins) 5th Edition. ISBN: 9780781789424
3. Malmivuo & Plonsey – Bioelectromagnetism- Principles and Applications of Bioelectric and Biomagnetic Fields (Oxford University Press) 1995<
Course Type: Elective Credit: 1
Description: The aim of this theory plus lab course is to provide insight of designing and prototyping of medical device. It will provide the basics and mechanisms of rapid prototyping, 3D design software, and 3D printing of prototype. In addition, it will also provide overview of various product designing and fabrication, such as the selection and development of material formulation, optimization of different processing conditions of the printing operation, and finally 3D printing of device prototype.
In this course, students will work in teams on a mini-project. They will select one medical device from the market, reverse engineer that and build a prototype of the same device. They will also prepare, present and defend a short scientific presentation.
Syllabus:
References:
Books:
1. A.D. Lantada (ed.), Handbook on Advanced Design and Manufacturing Technologies 19 for Biomedical Devices, DOI 10.1007/978-1-4614-6789-2_2.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
Description: The aim of this theory plus lab course is to provide insight of designing and prototyping of medical device. It will provide the basics and mechanisms of rapid prototyping, 3D design software, and 3D printing of prototype. In addition, it will also provide overview of various product designing and fabrication, such as the selection and development of material formulation, optimization of different processing conditions of the printing operation, and finally 3D printing of device prototype.
In this course, students will work in teams on a mini-project. They will select one medical device from the market, reverse engineer that and build a prototype of the same device. They will also prepare, present and defend a short scientific presentation.
Syllabus:
References:
Books:
1. A.D. Lantada (ed.), Handbook on Advanced Design and Manufacturing Technologies 19 for Biomedical Devices, DOI 10.1007/978-1-4614-6789-2_2.
2. Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
Course Type: Core Credit: 1
Description: This course is intended for practical handling experience for students for culture of mammalian cells. They should learn detailed step-wise protocols in culturing, freezing, splitting of mammalian cells. In addition, they should be able to see the cells found in blood.
Syllabus:
● Cell culture, splitting
● Cell freezing and thawing
● Identification of cells in blood smear
References:
Culture of animal cells. Editor: R. Ian Freshney. 6th edition.
Description: This course is intended for practical handling experience for students for culture of mammalian cells. They should learn detailed step-wise protocols in culturing, freezing, splitting of mammalian cells. In addition, they should be able to see the cells found in blood.
Syllabus:
● Cell culture, splitting
● Cell freezing and thawing
● Identification of cells in blood smear
References:
Culture of animal cells. Editor: R. Ian Freshney. 6th edition.
Course Type: Elective Credit: 2
Description:
Syllabus: Introduction to Micro Nano scale fluid flows and Mass transport – Navier Stokes equation, Convection Diffusion equation and analytical solutions for flows in rectangular channel cross sections – Flow field fractionation using Dielectrophoresis – Separaion and concentration of Cells on Chip using Acoustic, Magnetic and Optical fields – Microfabrication – materials - thin film deposition and patterning techniques – Bonding techniques – 3D/Multilayer fabrication of microfluidic Chips – Applications – Drug screening - SERS on Chip using magnetic nanoparticles – Single Cell trapping techniques on Chip – Stem Cell differentiation studies on Chip – Microfluidic PCR - Biochips for studies on Protein Folding.
References:
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.
Description:
Syllabus: Introduction to Micro Nano scale fluid flows and Mass transport – Navier Stokes equation, Convection Diffusion equation and analytical solutions for flows in rectangular channel cross sections – Flow field fractionation using Dielectrophoresis – Separaion and concentration of Cells on Chip using Acoustic, Magnetic and Optical fields – Microfabrication – materials - thin film deposition and patterning techniques – Bonding techniques – 3D/Multilayer fabrication of microfluidic Chips – Applications – Drug screening - SERS on Chip using magnetic nanoparticles – Single Cell trapping techniques on Chip – Stem Cell differentiation studies on Chip – Microfluidic PCR - Biochips for studies on Protein Folding.
References:
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.
Course Type: Elective Credit: 2
Description:
Syllabus: Isotropic and Anisotropic models of elasticity - Non linear models for soft tissue mechanics - Biofluid mechanics - Newtonian and Non-Newtonian fluids -Effect of constituents of blood and synovial fluid on viscosity - Navier Stokes equation and analytical solutions for flows in different geometries - Non-Newtonian flow modeling - Arteial Blood flow - Pulsatile flows in arteries and analytical solutions for transient velocity field and shear stress - Oscillatory wall shear stress and its significance - modeling of Spherical Aneurysms.
References:
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.
Description:
Syllabus: Isotropic and Anisotropic models of elasticity - Non linear models for soft tissue mechanics - Biofluid mechanics - Newtonian and Non-Newtonian fluids -Effect of constituents of blood and synovial fluid on viscosity - Navier Stokes equation and analytical solutions for flows in different geometries - Non-Newtonian flow modeling - Arteial Blood flow - Pulsatile flows in arteries and analytical solutions for transient velocity field and shear stress - Oscillatory wall shear stress and its significance - modeling of Spherical Aneurysms.
References:
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.
Course Type: Elective Credit: 2
Description:
Syllabus: Medical imaging systems: Ultrasound, Photoacoustic imaging, MRI, X rays and CT; Nuclear imaging techniques: PET, SPECT, Optical imaging and microscopy, Molecular and Cellular imaging, Contrast agents (6 Lectures + Lab).
References:
1.Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2.Fundementals of Photonics B. E A. Saleh and M. C. Teich John Wiley 2009.
3.Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.4."Additional materials distributed in class".
Description:
Syllabus: Medical imaging systems: Ultrasound, Photoacoustic imaging, MRI, X rays and CT; Nuclear imaging techniques: PET, SPECT, Optical imaging and microscopy, Molecular and Cellular imaging, Contrast agents (6 Lectures + Lab).
References:
1.Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2.Fundementals of Photonics B. E A. Saleh and M. C. Teich John Wiley 2009.
3.Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.4."Additional materials distributed in class".
Course Type: Elective Credit: 2
Description: This is a highly interdisciplinary course for graduate students (M. Tech, Ph. D) who are interested in learning about the emerging field of nanoscience and nanotechnology and its application in biology and medicine. To capture the excitement of this emerging field, in this coruse student will be familiarized with fundamentals of nanoscience and Nano-scale engineering, and their potential application in the human health care system. This course will emphasize emerging nanotechnologies and its biomedical applications including fundamental of nanomaterials and nanoengineering, notoxicology, nanotechnology for drug delivery, regenerative medicine, imaging, and diagnostic system and translating nano-medicines into clinical investigation.
Syllabus:
References:
1. Jain, Kewal K. The Handbook of Nanomedicine. Humana Press, 2008. ISBN-13: 978-1-6032-7318-3.
2. Nanomedicine Design of Particles, Sensors, Motors, Implants, Robots, and Devices. Ed. Mark J. Schulz, Vesselin N. Shanov, and Yeoheung Yun. Artech House, 2009. ISBN-13: 978-1-5969-3279-1.
3. Nanotechnology: Volume 5: Nanomedicine. Ed. Viola Vogel. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2009. ISBN-13: 978-3-5273-1736-3.
4. Nanotechnology in Biology and Medicine: Methods, devices, and applications. Ed. Tuan Vo-Dinh. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2007. ISBN-13: 978-0-8493-2949-4.
5.Tibbals, Harry F. Perspectives in Nanotechnology: Medical Nanotechnology and Nanomedicine. Ed. Gabor L. Hornyak. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2011. ISBN-13: 978-1-4398-0874-0.
6.Vladimir P.Torchilin, Nanoparticulates as Drug Carriers, Imperial College Press, North Eastern, University, USA (2006).
7. David E Reisner, Bionanotechnology, Global Preospects, CRC press (2008).
Description: This is a highly interdisciplinary course for graduate students (M. Tech, Ph. D) who are interested in learning about the emerging field of nanoscience and nanotechnology and its application in biology and medicine. To capture the excitement of this emerging field, in this coruse student will be familiarized with fundamentals of nanoscience and Nano-scale engineering, and their potential application in the human health care system. This course will emphasize emerging nanotechnologies and its biomedical applications including fundamental of nanomaterials and nanoengineering, notoxicology, nanotechnology for drug delivery, regenerative medicine, imaging, and diagnostic system and translating nano-medicines into clinical investigation.
Syllabus:
References:
1. Jain, Kewal K. The Handbook of Nanomedicine. Humana Press, 2008. ISBN-13: 978-1-6032-7318-3.
2. Nanomedicine Design of Particles, Sensors, Motors, Implants, Robots, and Devices. Ed. Mark J. Schulz, Vesselin N. Shanov, and Yeoheung Yun. Artech House, 2009. ISBN-13: 978-1-5969-3279-1.
3. Nanotechnology: Volume 5: Nanomedicine. Ed. Viola Vogel. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2009. ISBN-13: 978-3-5273-1736-3.
4. Nanotechnology in Biology and Medicine: Methods, devices, and applications. Ed. Tuan Vo-Dinh. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2007. ISBN-13: 978-0-8493-2949-4.
5.Tibbals, Harry F. Perspectives in Nanotechnology: Medical Nanotechnology and Nanomedicine. Ed. Gabor L. Hornyak. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2011. ISBN-13: 978-1-4398-0874-0.
6.Vladimir P.Torchilin, Nanoparticulates as Drug Carriers, Imperial College Press, North Eastern, University, USA (2006).
7. David E Reisner, Bionanotechnology, Global Preospects, CRC press (2008).
Course Type: Elective Credit: 2
Description: The students will learn how to test the biomaterials along with a number of cell types in vitro and in vivo. He should learn how the physiological cues are combined together with biomaterials for regenerative medicine point of view.
Syllabus: Tissue engineering: fundamentals and current status; Stem cells: embryonic and mesenchymal stem cells; cell differentiation; Extra-cellular matrix components and their regulation of cell behavior; In vitro and in vivo testing of biomaterials. Bioreactor; Cell migration; Growth factors; Different approaches for angiogenesis and its importance.
References:
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.
Description: The students will learn how to test the biomaterials along with a number of cell types in vitro and in vivo. He should learn how the physiological cues are combined together with biomaterials for regenerative medicine point of view.
Syllabus: Tissue engineering: fundamentals and current status; Stem cells: embryonic and mesenchymal stem cells; cell differentiation; Extra-cellular matrix components and their regulation of cell behavior; In vitro and in vivo testing of biomaterials. Bioreactor; Cell migration; Growth factors; Different approaches for angiogenesis and its importance.
References:
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.
Course Type: Elective Credit: 1
Description: The students will learn in a seminar-based manner about a number of tissue-specific regenerative medicine and various approaches to achieve this.
Syllabus: Tissue-specific regenerative medicine: Bone, cartilage. Regulation and ethics of tissue engineering; Advanced methods applied in regenerative medicine field.
References:
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.
Description: The students will learn in a seminar-based manner about a number of tissue-specific regenerative medicine and various approaches to achieve this.
Syllabus: Tissue-specific regenerative medicine: Bone, cartilage. Regulation and ethics of tissue engineering; Advanced methods applied in regenerative medicine field.
References:
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.
Course Type: Elective Credit: 2
Description: This course is a first pass through the principles of working of the brain from the level of a single neuron to systems and behaviour. The course focuses on characterising the operating principles of the brain at various levels and the mathematical models used to represent them. The objective of the course is to develop in students an ability to convert concepts in neurophysiology into a mathematical model.
Syllabus: Genesis of electrical activity in cells, resting membrane potentials; Neuron equivalent circuits and passive propagation in neurons; Hodgkin-Huxley equations and conductance based models; Ion channels and their diversity; Simple neuron models and analysis using dynamical systems concepts; Chemical and electrical synapses and their models; Neuronal networks and techniques for mathematical analysis; Models of learning and memory in the neuron and the network; Models of cognition, decision making and psychophysical models; Systems (sensory and motor systems) and their modeling; Neural coding (Rate, temporal, population); Neuronal data analysis techniques (Pre-processing, Spike detection and sorting techniques).
References:
1. Foundations of Cellular Neurophysiology, Johnston and Wu, (2011).
2. Mathematical foundations of Neuroscience, Ermentrout and Terman (2012).
Description: This course is a first pass through the principles of working of the brain from the level of a single neuron to systems and behaviour. The course focuses on characterising the operating principles of the brain at various levels and the mathematical models used to represent them. The objective of the course is to develop in students an ability to convert concepts in neurophysiology into a mathematical model.
Syllabus: Genesis of electrical activity in cells, resting membrane potentials; Neuron equivalent circuits and passive propagation in neurons; Hodgkin-Huxley equations and conductance based models; Ion channels and their diversity; Simple neuron models and analysis using dynamical systems concepts; Chemical and electrical synapses and their models; Neuronal networks and techniques for mathematical analysis; Models of learning and memory in the neuron and the network; Models of cognition, decision making and psychophysical models; Systems (sensory and motor systems) and their modeling; Neural coding (Rate, temporal, population); Neuronal data analysis techniques (Pre-processing, Spike detection and sorting techniques).
References:
1. Foundations of Cellular Neurophysiology, Johnston and Wu, (2011).
2. Mathematical foundations of Neuroscience, Ermentrout and Terman (2012).
Course Type: Core Credit: 1
Description: Students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering.
Syllabus:
References:
1.Zenos, Makover, P. Yock, Biodesign, Cambridge University Press (2009).
2. Resources distributed in class.
Description: Students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering.
Syllabus:
References:
1.Zenos, Makover, P. Yock, Biodesign, Cambridge University Press (2009).
2. Resources distributed in class.
Course Type: Elective Credit: 1
Description: This course is intended for basic understanding of human physiology with respect to peripheral neurons and muscles in the engineers’ perspective. The students need to understand the cellular and physiological systems with respect to peripheral neurons, neuromuscular junction and skeletal muscles. Action potential and electrical conductivity of peripheral neurons will be covered.
Syllabus: ● Peripheral neurons and their function
● Skeletal muscle and their functions
● Action potential and electrical conductivity
● Neuro-muscular junction
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Description: This course is intended for basic understanding of human physiology with respect to peripheral neurons and muscles in the engineers’ perspective. The students need to understand the cellular and physiological systems with respect to peripheral neurons, neuromuscular junction and skeletal muscles. Action potential and electrical conductivity of peripheral neurons will be covered.
Syllabus: ● Peripheral neurons and their function
● Skeletal muscle and their functions
● Action potential and electrical conductivity
● Neuro-muscular junction
References:
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.
Course Type: Elective Credit: 2
Description: This course is intended for practical handling experience for students for molecular biology techniques such as DNA isolation, RNA isolation, polymerase chain reaction, and transfection. They should also learn basic molecular biology methods and their interpretation with respect to cell culturing techniques. Prior knowledge of mammalian cell culture is mandatory for this course.
Syllabus:
● DNA, RNA isolation
● PCR reaction
● Transfection
● Western blotting
● Immunohistochemistry
● Cytoskeleton staining
References:
1. Molecular Cloning: A Laboratory Manual (3 Volume Set) Dec 1989 by J. Sambrook and E.F. Fritsch.
2. Molecular Cell Biology, 2012 by Harvey Lodish and Arnold Berk.
Description: This course is intended for practical handling experience for students for molecular biology techniques such as DNA isolation, RNA isolation, polymerase chain reaction, and transfection. They should also learn basic molecular biology methods and their interpretation with respect to cell culturing techniques. Prior knowledge of mammalian cell culture is mandatory for this course.
Syllabus:
● DNA, RNA isolation
● PCR reaction
● Transfection
● Western blotting
● Immunohistochemistry
● Cytoskeleton staining
References:
1. Molecular Cloning: A Laboratory Manual (3 Volume Set) Dec 1989 by J. Sambrook and E.F. Fritsch.
2. Molecular Cell Biology, 2012 by Harvey Lodish and Arnold Berk.
Course Type: Elective Credit: 1
Description: This course focuses on a design process thinking for Innovations in healthcare. The prerequisite for this course is BM 6146 clinical immersion. The curriculum aims at exposing the students to unmet needs in the clinic and introduce a systematic design process thinking to arrive a solution to the problems. The course will have detailed case studies and problem-based learning sessions on Biodesign.
Syllabus:
References:
1. Zenos, Makover, P. Yock, Biodesign, Cambridge University Press (2009)
2. Resources distributed in class
Description: This course focuses on a design process thinking for Innovations in healthcare. The prerequisite for this course is BM 6146 clinical immersion. The curriculum aims at exposing the students to unmet needs in the clinic and introduce a systematic design process thinking to arrive a solution to the problems. The course will have detailed case studies and problem-based learning sessions on Biodesign.
Syllabus:
References:
1. Zenos, Makover, P. Yock, Biodesign, Cambridge University Press (2009)
2. Resources distributed in class